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KMID : 0043319980210060753
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Archives of Pharmacal Research
1998 Volume.21 No. 6 p.753 ~ p.758
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Synthesis and Biological Evaluation of Novel 2-[Substituted acetly]-amino-5-alkyl]-amino-5-alkyl-1,3,4-thiadiazoles
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Shakya Ashok K.
Mishra Pradeep
Patnaik G.K.
Shukla Rakesh
Srimal R.C.
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Abstract
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Sixteen novel 2-substituted acetyl amino-5-alkyl-1,3,4-thiadiazol were synthesized and screened for their pharmacological activities. A few of the compounds namely 11, 12 and 16 showed anti-inflammatory activities comparable to phenylbutazone. Compound 12 also showed significan non-specific spasmolytic activity. Diuretic activity of compound 15 at a dose level of 90mg/kg p.o. was two fold higher compared to 50mg/kg p.o. of furosemide. Comparable diuresis was aso produced by compounds 9, 10, and 16.
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KEYWORD
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2-[Substituted acetyl]-amino-5-alkyl-1, 3, 4-thiadiazoles, 2-[Substituted-ethanamido]-5-alkyl-1, 3, 4-thiadiazoles, 1, 3, 4-Thiadiazole, Diruetic, Anti-inflammatory agent
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